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Tuesday, April 21, 2026 at 6:10 PM EDT

Houston Astros @ Cleveland Guardians

HOU @ CLE

HOU
5
CLE
8
Final

Moneyline

HOU
41%
59%
CLE
+138-154

ML Edge

HOU+9.9%
CLE-9.9%

Total (O/U)

8.0

BetUS

Over+1.9%
Under-1.9%

Venue

Park Factor

1.00

Neutral

Away Starter

Ryan Weiss
Team:Houston Astros (HOU)
Pitcher:Ryan Weiss(RHP)
Record:0-2
ERA:6.50

Home Starter

Parker Messick
Team:Cleveland Guardians (CLE)
Pitcher:Parker Messick(RHP)
Record:3-0
ERA:1.76

💡 Betting Insights

Key takeaways for this matchup

💰

HOU ML has a 9.9% edge — the market may be undervaluing them.

Pitching matchup: Ryan Weiss (6.50 ERA) vs Parker Messick (1.76 ERA).

Player Props

Player props for this game

No player props available yet

Props are typically available 12-24 hours before game time

📊 Box Score

Final game statistics

Houston Astros (HOU)

BatterABRHRBIBBSOHR
Carlos CorreaSS4021110
Yordan AlvarezDH5023000
Jose Altuve2B5000020
Christian Walker1B4000000
Isaac Paredes3B3110100
Cam SmithRF4120010
Yainer DiazC4110000
Brice MatthewsLF3121010
Dustin HarrisLF1100000
Daniel JohnsonCF0000100
Pitching
PitcherIPHRERBBSOPC
Kai-Wei Teng2.20001231
Ryan Weiss3.15224486
Enyel De Los Santos0.12331015
Bryan King0.22332015
Colton Gordon1.02000117

Cleveland Guardians (CLE)

BatterABRHRBIBBSOHR
Steven KwanCF3110200
Chase DeLauterDH4113100
José Ramírez3B3210200
Kyle Manzardo1B4022100
George ValeraRF5011010
Daniel Schneemann2B2110210
Angel MartínezLF4221021
Austin HedgesC2010010
Bo NaylorC2000010
Brayan RocchioSS4111010
Pitching
PitcherIPHRERBBSOPC
Shawn Armstrong1.00000011
Connor Brogdon0.11100011
Cade Smith1.02111118
Peyton Pallette1.00001021
Parker Messick5.06331485
Tim Herrin0.21000016

Pitcher Matchup Analysis

Platoon splits, recent form, and times through the order

Ryan Weiss (HOU)

2026 season
vs CLE
ERA
5.40
IP
3.1
W-L
0-0
K
4
WHIP
2.90
AVG
.333
SplitERAWHIPK/9BB/9AVGIP
Overall6.502.1711.07.0.32518.0
Home4.051.7711.68.7.2176.2
Away7.942.5211.46.5.37011.1
Last 7 Days5.402.9011.611.6.3333.1
Last 30 Days6.352.1210.66.9.31917.0
Opponent Batting by Handedness
SplitAVGOBPSLGOPSABK
vs LHB.333.439.521.9594814
vs RHB.310.412.6211.032298
Times Through Order
TimeAVGOBPSLGOPSABK
1st Time.320.424.500.9245014
2nd Time.320.433.6801.113257
3rd Time.500.500.5001.00021

Parker Messick (CLE)

2026 season
vs HOU
ERA
5.40
IP
5.0
W-L
0-0
K
4
WHIP
1.40
AVG
.333
SplitERAWHIPK/9BB/9AVGIP
Overall1.760.898.62.4.18330.2
Home3.000.899.53.0.16718.0
Away0.000.907.41.5.20512.2
Last 7 Days5.401.407.21.8.3335.0
Last 30 Days1.760.898.62.4.18330.2
Opponent Batting by Handedness
SplitAVGOBPSLGOPSABK
vs LHB.188.278.188.465327
vs RHB.181.234.278.5127222
Times Through Order
TimeAVGOBPSLGOPSABK
1st Time.163.200.256.4564312
2nd Time.179.289.205.4943911
3rd Time.227.261.318.579226

Last 5 Games

Not available yet

Season Series

This Series (3 games)
HOU wins series 2-1
Season (6 games)
Series tied 1-1

Weather

Not available yet

Recent Odds

Latest betting lines from various books

Moneyline

BookAwayHomeTime
BetUS+138-1544:38 PM
Bovada+139-1644:38 PM
BetRivers+130-1614:38 PM
BetMGM+135-1614:38 PM
Caesars+140-1644:38 PM

Totals

BookTotalOverUnderTime
BetUS8.0-105-1154:38 PM
Bovada8.5-115-1054:38 PM
BetRivers8.0-109-1144:38 PM
BetMGM8.0+100-1204:38 PM
Caesars8.0-105-1154:38 PM